How does prodrug metabolism enhance the gastrointestinal safety...

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2026-07-27 07:03:24 -

How does prodrug metabolism enhance the gastrointestinal safety profile of loxoprofen sodium?

Loxoprofen sodium is a non-steroidal anti-inflammatory drug that exhibits analgesic, anti-inflammatory, and antipyretic therapeutic properties. Administered orally as an inactive prodrug, it undergoes hepatic conversion via reduction into its active trans-alcohol metabolite, which inhibits cyclooxygenase enzymes to suppress prostaglandin synthesis. This prodrug mechanism minimizes direct...

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